Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy
نویسندگان
چکیده
منابع مشابه
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.
The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of dopaminergic transmission at the D(2) receptor. We measured in vivo occupancy of striatal D(2) receptors by dopamine in 18 untreated patients with schizophrenia and 18 matched controls, by comparing D(2) receptor availability before and during pharmacologically induced acute dopamine depletion. Acute depletion of i...
متن کاملTargeting the dopamine D2 receptor in schizophrenia.
After a 12-year search for the antipsychotic receptor, the binding site was discovered and labelled by [3H]haloperidol in 1975. Of the various neurotransmitters, dopamine was the most potent in inhibiting the binding of [3H]haloperidol, indicating that the antipsychotic receptor was a dopamine receptor, now named the dopamine D2 receptor, a major targeting site in schizophrenia. All antipsychot...
متن کاملDopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data.
INTRODUCTION Antipsychotic drugs exert antipsychotic effects by blocking dopamine D2 receptors in the treatment of schizophrenia. However, effects of D2 receptor blockade on neurocognitive function still remain to be elucidated. The objective of this analysis was to evaluate impacts of estimated dopamine D2 receptor occupancy with antipsychotic drugs on several domains of neurocognitive functio...
متن کاملHyperprolactinemia and estimated dopamine D2 receptor occupancy in patients with schizophrenia: Analysis of the CATIE data
BACKGROUND Large-scale data are still lacking on the relationship between serum prolactin concentration and dopamine D2 receptor occupancy in patients with schizophrenia treated with antipsychotics. METHODS The dataset from 481 subjects (risperidone, N = 172, olanzapine, N = 211, and ziprasidone, N = 98) who participated in Phase 1 of the Clinical Antipsychotic Trials in Intervention Effectiv...
متن کاملPET imaging of dopamine-D2 receptor internalization in schizophrenia
This corrects the article DOI: 10.1038/mp.2017.107.
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2015
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-015-1846-4